Nattokinase
Looking to buy Nattokinase? Nattokinase is an enzyme formed during the production of natto, a traditional Japanese food made from fermented soya beans. Nattokinase supplements contain a measured amount of this enzyme, with enzyme activity usually expressed in FU. On this page, you can read about what Nattokinase is, where it comes from and what to look for when comparing supplements.
By Stefan, last updated: 08-09-2026.
Contents
- Our favourite Nattokinase supplement
- What is Nattokinase?
- What are its origins and history?
- Does Nattokinase have any side effects?
Our favourite Nattokinase supplement
What is Nattokinase?
Nattokinase is an enzyme produced during the fermentation of soya beans by the bacterium Bacillus subtilis var. natto. An enzyme is a protein that can speed up certain chemical reactions. Nattokinase belongs to a group of enzymes called proteases.
For food supplements, Nattokinase is extracted from the fermented material and made into capsules or tablets, for example. The amount of the ingredient may be stated in milligrams, but this does not tell you everything about its enzyme activity. The unit FU is usually used for this.
What are its origins and history?
The history of Nattokinase is closely linked to Japanese food culture. People in Japan have been eating 'natto' for more than a thousand years. This is a sticky, fermented soya bean product traditionally eaten for breakfast. Although its distinctive flavour and texture mean it is not to everyone's taste, natto has always been valued in Japanese tradition.
Scientific research into natto only really gained momentum later. In the 1980s, researchers identified Nattokinase as the active enzyme responsible for the fermented product's unique properties. Since then, Nattokinase has been isolated and standardised, making it available as a supplement to people around the world looking for this specific natural substance without having to eat fermented soya beans.
Does Nattokinase have any side effects?
If you are considering taking a supplement such as Nattokinase, it is always sensible to be well informed about how your body may react to new substances.
Side effects may occur, such as mild stomach or intestinal discomfort. Consult a doctor or pharmacist before use if you take anticoagulants or other medicines that affect blood clotting. You should also do this if you have a blood clotting disorder, are pregnant or breastfeeding, or are due to have surgery or another medical procedure. Always take note of the warnings and restrictions on use for the specific product.
Do you have a question about a product's ingredients, dosage or instructions for use? Please feel free to contact us. For personal medical advice, it is best to speak to a doctor or pharmacist.
Our mission is to help people choose their health products with the right information
Yes. Nattokinase is an enzyme produced during the fermentation process used to make natto. It is therefore also described as an enzyme from fermented soya beans.
Natto is a traditional food made from fermented soybeans. Nattokinase is an enzyme produced during the fermentation process. A supplement contains a concentrated amount of Nattokinase and is usually available in capsules.
FU is a measure of the enzyme activity of Nattokinase. One of the Nattokinase supplements in our range contains 2,000 FU per capsule. This means that each capsule provides 2,000 FU of enzyme activity. When comparing products, always check the number of FU per capsule and per recommended daily dose, as a serving of some supplements consists of several capsules. Always follow the directions for use on the label.
When choosing a product, compare factors such as the amount of Nattokinase per capsule, the ingredients, the number of capsules and the information the manufacturer provides about the product. This makes it easier to compare different products side by side.
Recommended use may vary between nattokinase supplements. Always follow the dosage and timing instructions on the label of the specific product. Do not exceed the recommended daily dose. Are you taking medication or unsure about the best time to take it? Speak to a doctor or pharmacist.